abstract：:The carcinogenic effectiveness of nitrosomethyl-n-butylamine,-n-hexylamine and -n-heptylamine was compared by administration to F344 rats at various concentrations in drinking water and by gavage in oil. Nitrosomethylbutylamine induced only tumors of the upper gastrointestinal tract, and was very toxic. Nitrosomethylh...

journal_title：Journal of cancer research and clinical oncology

authors： Lijinsky W,Reuber MD,Singer GM

更新日期：1983-01-01 00:00:00

abstract：:In the supernatant of melanoma cell culture SK mel 25 three indolic compounds - 5-hydroxy-6-methoxyindole, 5-hydroxy-6-methoxyindolyl-2-carboxylic, and 6-hydroxy-5-methoxyindolyl-2-carboxylic acids - have been identified. The supernatants were extracted with ethyl acetate, derivatized, and analyzed by gas chromatograp...

journal_title：Journal of cancer research and clinical oncology

authors： Pavel S,Muskiet FA,de Ley L,The TH,van der Slik W

更新日期：1983-01-01 00:00:00

abstract：:Aclacinomycin A (ACM) is a new anthracycline antibiotic with a reduced cardiac toxicity in animal models. A phase II study was performed in a total of 25 patients, 23 of whom are evaluable for response. All suffered from recurrent and advanced tumors. Pretreatment consisted of at least four different chemotherapeutic ...

journal_title：Journal of cancer research and clinical oncology

authors： Schütte J,Niederle N,Seeber S

更新日期：1983-01-01 00:00:00

abstract：:Female wistar rats were fed on an Mg-deficient diet. After 8 to 10 weeks, the thymus glands were strongly degenerated and the number of lymphocytes was reduced, especially in the cortex. Thymus degeneration was associated with a decreased rate of DNA, RNA, and protein biosynthesis and necrosis and phagocytosis of lymp...

journal_title：Journal of cancer research and clinical oncology

authors： Averdunk R,Bippus PH,Günther T,Merker HJ

更新日期：1982-01-01 00:00:00

abstract：:This paper confirms previous results that hyperglycemia (5 g/l) lasting 250 min, when combined with local hyperthermia (43 degrees C) for the last 100 min, strongly inhibits microcirculation in Yoshida sarcomas and DS-carcinosarcomas. This inhibition occurs independently of heparinization of the animals (700 IU/200 G ...

journal_title：Journal of cancer research and clinical oncology

authors： von Ardenne M,Reitnauer PG

更新日期：1982-01-01 00:00:00

abstract：:Syrian golden hamsters received weekly s.c. doses of 5.0, 2.5, 1.25 or 0.63 mg/kg b.w. vinylethylnitrosamine (VEN). As dose levels increased, average survival time decreased, tumor multiplicity increased as did the total tumor rate which was between 50% and 100%. The main target of VEN effect was the respiratory tract...

journal_title：Journal of cancer research and clinical oncology

authors： Green U,Althoff J

更新日期：1982-01-01 00:00:00

abstract：:The hospital records of 60 female and 56 male pancreatic cancer patients and 232 age-, race-, sex-, and hospital-matched controls were reviewed for evidence of prior thyroid disease, cholecystectomy, appendectomy, alcohol consumption and among females, for diseases for the endometrium and ovary. No statistically signi...

journal_title：Journal of cancer research and clinical oncology

authors： Haines AP,Moss AR,Whittemore A,Quivey J

更新日期：1982-01-01 00:00:00

abstract：:The distribution, size, and configuration of intercellular junctions in the sebaceous tumor of mice were examined using the freeze-fracture technique. Three types of junctions were observed: desmosomes, gap, and tight junctions. Tight junctions in general consisted of short linear unbranched fibrils, and macular or co...

journal_title：Journal of cancer research and clinical oncology

authors： Robenek H,Schöpper C,Fasske E,Fetting R,Themann H

更新日期：1982-01-01 00:00:00

abstract：:After a single pulse dose of DMBA, rats develop bone-marrow hypoplasia, which is almost compensated for by regeneration after 16 weeks. Subsequently, dysplastic signs of hemopoiesis appear in all experimental animals as massive extrusion of normoblasts into the peripheral blood, red-cell aniso- and poikilocytosis, nuc...

journal_title：Journal of cancer research and clinical oncology

authors： Fohlmeister I,Schaefer HE,Fischer R

更新日期：1982-01-01 00:00:00

abstract：:Bleomycin was injected i.p. in rats, and the amount of expired ethane which indicates lipid peroxidation was followed up for 78 h. Compared to controls neither 1 x 30 mg/kg and 2 x 30 mg/kg nor 1 x 70 mg/kg bleomycin led to increased ethane expiration, although body weight loss indicated toxicity. That pulmonary toxic...

journal_title：Journal of cancer research and clinical oncology

authors： Muliawan H,Burkhardt A,Scheulen ME,Kappus H

更新日期：1982-01-01 00:00:00

abstract：:Tissue sections of frozen biopsy specimens obtained from normal and hyperplastic human lymphoid tissues as well as 40 cases of non-Hodgkin's lymphomas were analysed in immunofluorescence tests (using red TRITC and green FITC double-labeling). A panel of antisera including well-characterized conventional reagents to im...

journal_title：Journal of cancer research and clinical oncology

authors： Janossy G,Thomas JA,Pizzolo G

更新日期：1981-01-01 00:00:00

abstract：:We report about an extremely rare case of malignant fibrous histiocytoma (MFH) of the renal capsule. The tumor is composed of fibroblast-like cells arranged in a storiform pattern and histiocyte-like cells with multinucleated giant cells, both showing no iron reaction. Characteristic of the histiocytic quality of the ...

journal_title：Journal of cancer research and clinical oncology

authors： Gabbert H,Wagner R,Becht E

更新日期：1981-01-01 00:00:00

abstract：:Ftorafur (FT), a 2-tetrahydrofuryl derivative of 5-fluorouracil (5-FU) was introduced into cancer chemotherapy with the hope to obtain a therapeutic effect comparable to 5-FU with a smaller dose and less side effects. A comparison of the effect of FT and 5-FU on the proliferation of L 1210 ascites tumor cells in the p...

journal_title：Journal of cancer research and clinical oncology

authors： Schultze B,Jellinghaus W,Weis G,Müller V,Maurer W

更新日期：1981-01-01 00:00:00

abstract：:The responsiveness of spleen cells from C57BL/6J mice to various immunogenic stimuli was examined during the progressive growth of a poorly immunogenic fibrosarcoma T241. A strong correlation was observed between the progressive tumor growth and the depression of response to Concanavalin A, lipopolysaccharide, sheep r...

journal_title：Journal of cancer research and clinical oncology

authors： Gautam SC,Gautam S,Deodhar SD

更新日期：1981-01-01 00:00:00

abstract：:Metabolic activation steps involved in carcinogenesis by several aromatic amines, their N-acetylated derivatives, and dialkylnitrosamines are reviewed. N-Hydroxylation is the first activation step in the carcinogenesis by 2-acetylaminofluorene (AAF), other aromatic amides and amines. The cytochrome P-450 enzyme system...

journal_title：Journal of cancer research and clinical oncology

authors： Lotlikar PD

更新日期：1981-01-01 00:00:00

abstract：:In a wider sense iatrogenic carcinogenesis means the induction of cancer by medical treatment. Some drugs have been now identified to be carcinogenic not only in experimental animals but also in man. For example, chlornaphazine used in the treatment of polycythemia has been proved to induce bladder cancer in 30% of th...

journal_title：Journal of cancer research and clinical oncology

authors： Schmähl D

更新日期：1981-01-01 00:00:00

abstract：:Correlations between exposure to vinyl chloride and the development of malignant tumors in the liver have been know since 1974 and have been confirmed by many an experimental investigation. Based on the evaluation of mortality statistics from nine different countries an increased incidence of malignant tumors of the l...

journal_title：Journal of cancer research and clinical oncology

authors： Emmerich KH,Norpoth K

更新日期：1981-01-01 00:00:00

abstract：:A total of 30 inbred Wistar rats were orally administered 70 microgram/ml solution of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) for 35 weeks and then tap water for the following 20 to 30 weeks. Four of the 20 females and two of ten males developed carcinoids in the glandular stomach, but no metastasis could be found...

journal_title：Journal of cancer research and clinical oncology

authors： Tahara E,Ito H,Nakagami K,Shimamoto F

更新日期：1981-01-01 00:00:00

abstract：:A short-term organ culture of rat tracheal epithelium was used to detect the ability of 53 chemicals to induce UDS. In this system all direct-acting compounds (ultimate or proximate carcinogens) tested induced UDS. Of 24 compounds requiring metabolism (procarcinogens), nine induced UDS, viz., 4NQO, AF-2, BP, DMN, DEN,...

journal_title：Journal of cancer research and clinical oncology

authors： Ide F,Ishikawa T,Takayama S

更新日期：1981-01-01 00:00:00

abstract：:The formation of foci with loss of ATPase and emergence of gamma-GTase was studied histochemically in livers of male and female Wistar and Sprague-Dawley rats of 3--4 and 6--7 weeks of age, respectively, after application of diethylnitrosamine. A single dose of 8 mg/kg body weight induced a considerable island formati...

journal_title：Journal of cancer research and clinical oncology

authors： Deml E,Oesterle D,Wolff T,Greim H

更新日期：1981-01-01 00:00:00

abstract：:Intravenous tumor cell injection and spontaneously metastasising transplantable tumors have been used as models for haematogenous tumor spread. To evaluate the validity of these two experimental approaches for the study of blood coagulability and metastases, the effect of anticoagulants on "secondary" tumor growth was...

journal_title：Journal of cancer research and clinical oncology

authors： Maat B,Hilgard P

更新日期：1981-01-01 00:00:00

abstract：:A brain metastasis of bronchial squamous cell carcinoma in a patient was cultivated. The cells with epithelium-like characteristics were selected from the primary culture, and were subcultured to establish a cell line. The cultured cells were identified to be neoplastic by means of heterologous transplantation to nude...

journal_title：Journal of cancer research and clinical oncology

authors： Takaki T

更新日期：1980-01-01 00:00:00

abstract：:A transplantable non-immunogenic murine carcinoma of spontaneous origin, WHT Carcinoma N-C (Hewitt), was used to assess the effectiveness of melphalan (Ml) and/or methotrexate (Mx) for treatment of occult metastatic disease following surgical excision of primary tumors. Early surgical excision alone cured 66% of mice;...

journal_title：Journal of cancer research and clinical oncology

authors： Zebro T,Wright EA

更新日期：1980-01-01 00:00:00

abstract：:The DMBA-TPA-mediated two-stage skin carcinogenesis experiment was modified in that pregnant mice were systemically treated once during pregnancy with the carcinogen. Intragastric application times were fetal days 6, 8, and 10-20. A control group of pregnant mice received repeated doses (from days 8-20) of sesame oil,...

journal_title：Journal of cancer research and clinical oncology

authors： Goerttler K,Loehrke H,Schweizer J,Hesse B

更新日期：1980-01-01 00:00:00

abstract：:Sequential studies were made on the histopathologic changes in the glandular stomach of rats induced by a weak carcinogen. N-propyl-N'-nitro-N-nitrosoguanidine (PNNG). Fiftyfour rats were given 100 micrograms/ml of PNNG in their drinking water for 44 weeks, and then normal tap water until the end of the experiment. Ra...

journal_title：Journal of cancer research and clinical oncology

authors： Matsukura N,Itabashi M,Kawachi T,Hirota T,Sugimura T

更新日期：1980-01-01 00:00:00

abstract：:The epoxide hydratase inhibitor, 1,1,1-trichloro-2,3-propene oxide (TCPO) in combination with benzo[a]pyrene (B[a]P) was injected s.c. in ddN mice. The formation of fibrosarcoma by B[a]P was slightly accelerated at low dose of TCPO, and remarkably inhibited at high dose of TCPO. The correlation of carcinogenesis with ...

journal_title：Journal of cancer research and clinical oncology

authors： Kodama M,Ioki Y,Nagata C

更新日期：1980-01-01 00:00:00

abstract：:The study shows inhibition of the antitumor effect of cyclophosphamide (CPA) on mammary carcinomas growing in mice prior-immunized by intragastric inoculations of the tumor. Immunization with tumor cells through this route produces under certain conditions factors able to modulate the antigenic determinants on tumor c...

journal_title：Journal of cancer research and clinical oncology

authors： Laursen ML

更新日期：1980-01-01 00:00:00

abstract：:The levels of total human serum RNAase activity (HSRA) from 24 patients with ovarian cancer have been followed up for a period of over 5 months. The determinations of HSRA were carried out according to our assay system described earlier. Two representative patterns of the HSRA are presented, one from a patient with an...

journal_title：Journal of cancer research and clinical oncology

authors： Schleich HG,Wiest W

更新日期：1980-01-01 00:00:00

abstract：:The extent of ethylation of guanine in 7 N and O 6 position in rat liver DNA was studied after chronic feeding with unlabelled nitrosodiethylamine followed by a single application of the 14C labelled drug. Disulfiram inhibits the alkylation of rat liver DNA. It was also shown that a discontinuous dosage of disulfiram ...

journal_title：Journal of cancer research and clinical oncology

authors： Frank N,Hadjiolov D,Bertram B,Wiessler M

更新日期：1980-01-01 00:00:00

abstract：:After the gavage of 200 mg N-nitrosodiethylamine per kg body weight only kidney tumors developed while long-term administration of 10 ppm N-nitrosodiethylamine induced esophageal tumors and hepatocellular carcinomas in female rats (SIV 50). This change of the organ-specific carcinogenic effect is not observed in exper...

journal_title：Journal of cancer research and clinical oncology

authors： Schweinsberg F,Kouros M,Manncke K

更新日期：1979-10-01 00:00:00

abstract：:Cell proliferation kinetics of the urinary bladder urothelium have been analyzed in a total of 218 female Wistar rats after partial cystectomy. After one-third resection of the bladder DNA synthesis started 15 h postoperatively in the bladder stump and reached its maximum at 25 h with a mean 3H-TdR index of 10.1%. In ...

journal_title：Journal of cancer research and clinical oncology

authors： Kunze E,Albrecht H,Wöltjen HH,Schauer A

更新日期：1979-10-01 00:00:00

abstract：:The cytostatic drugs Chlorambucil and Bleomycin were labeled with 131I and with 57Co, respectively: Ruthenocenealdehyde-(N-methyl-N-beta-chlorethyl)-hydrazone and Ruthenocene-3-phenyl-prop.1-en-3-one were labeled with the gamma emitter 103Ru. In tumor-bearing mice the elimination and organ distribution of these radioa...

journal_title：Journal of cancer research and clinical oncology

authors： Wenzel M,Schneider M,Bier J,Benders P,Schachschneider G

更新日期：1979-10-01 00:00:00

abstract：:After cure of rat leukemia L 5222 in 79 BD IX rats by single doses of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) or 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea (Hydroxyethyl-CNU) a total of 9 rats (11%) developed secondary malignomas. ...

journal_title：Journal of cancer research and clinical oncology

authors： Zeller WJ,Schmähl D

更新日期：1979-09-01 00:00:00

abstract：:Mononuclear cells from peripheral blood and draining lymph nodes of 40 patients with invasive mammary carcinoma were examined for various immunological cell surface markers including surface membrane immunoglobulins and rosetting properties (E, EA, EAC). No significant relationship could be established to anyone of th...

journal_title：Journal of cancer research and clinical oncology

authors： Heidenreich W,Jagla K,Schüssler J,Börner P,Dehnhard F,Deinhardt J,Kalden J,Peter HH,Deicher H

更新日期：1979-09-01 00:00:00

abstract：:Metastatic interstitial cell tumor of the testis is one of the rarest human neoplasms. This is the nineteenth case to be reported. While most of these tumors are combined with hormonal dysfunction, the present tumor, apart from its uncommon hormonal profile, is remarkable because of its capacity of producing and secre...

journal_title：Journal of cancer research and clinical oncology

authors： Higi M,Niederle N,Scheulen ME,Richter HJ

更新日期：1979-07-27 00:00:00

abstract：:Three thousand Yoshida sarcoma cells were inoculated into the wall of the descending colon of each of 120 male Sprague-Dawley rats. On day 8 after the tumor implantation, the animals were at random divided into four groups of 30 rats each. The effect of cyclophosphamide (70 mg/kg), BCNU (25 mg/kg), and methyl-CCNU (45...

journal_title：Journal of cancer research and clinical oncology

authors： Bhide S,Habs M,Reinbold H,Schmähl D

更新日期：1979-05-14 00:00:00

abstract：:The increase of plasma cortisol in patients with tumors of five different sites compared with a control group of patients with benign surgical diseases amounted to: +39% (breast), +34% (stomach), +86% (intestine), +60% (skin) and +194% (gall bladder). The first detectable increase of cortisol occurred in patients with...

journal_title：Journal of cancer research and clinical oncology

authors： Schaur RJ,Semmelrock HJ,Schauenstein E,Kronberger L

更新日期：1979-04-12 00:00:00

abstract：:The uptake of tritiated N,N-bis(2-chloroethyl)-diamido-phosphoric-acid into Ehrlich-Ascites-Tumor cells of mice was studied by means of the siliconoil-filtration technique. At 10 mM concentration no permeation of the metabolite into the tumor cells could be found within 5 min at 1 degrees C, while its congenors cyclop...

journal_title：Journal of cancer research and clinical oncology

authors： Lenssen U,Hohorst HJ

更新日期：1979-02-19 00:00:00